婚後，茉莉跟隨丈夫巡迴佈道，但緊密的行程令她吃不消，只好留在家裡等待丈夫。如此一來，安定平凡的家庭生活對茉莉來說是奢侈的。從1758年，即婚後七年開始，茉莉多次離家出走。十三年後，即1771年，茉莉終於離開約翰。約翰在日記裡寫道：「我没有遺棄她，我没有離婚，我也不會要她回來。」他們至死不再相見，約翰也終身膝下無兒。
這段悲傷的情史，確實令人唏噓；但約翰‧衞斯理所創立的聖潔會 (Holy Club)，為幫助信徒在每日靈修中自我省察而提出的22道問題卻值得我們恆常思考：
1. Am I consciously or unconsciously creating the impression that I am better than I really am? In other words, am I a hypocrite? (我是否有意無意地把自己塑造成優於真我的形象？換言之，我是否假冒為善？)
2. Am I honest in all my acts and words, or do I exaggerate? (我所言所行真實無偽，抑或誇大其詞？)
3. Do I confidentially pass on to another what was told to me in confidence? (我是否把別人私下告訴我的事，悄悄地傳出去？)
4.Can I be trusted? (我是否可信賴？)
5. Am I a slave to dress, friends, work, or habits? (我是衣飾、朋友、工作或習慣的奴隸嗎？)
6. Am I self-conscious, self-pitying, or self-justifying? (我是自我醒覺、自憐或自義嗎？)
7.Did the Bible live in me today? (聖經今天活在我裡面嗎？)
8. Do I give it time to speak to me everyday? (我每天都安排時間讓聖經對我說話嗎？)
9.Am I enjoying prayer? (我享受禱告嗎？)
10.When did I last speak to someone else about my faith? (我上次向人分享信仰是甚麼時候呢？)
11.Do I pray about the money I spend? (我會為怎樣花費金錢而禱告嗎？)
12.Do I get to bed on time and get up on time? (我準時就寢，按時起床嗎？)
13.Do I disobey God in anything? (我在何事上不順服上帝？)
14.Do I insist upon doing something about which my conscience is uneasy? (我會堅持做一些令自己良心不安的事嗎？)
15.Am I defeated in any part of my life? (我生命中有哪方面被打敗了？)
16.Am I jealous, impure, critical, irritable, touchy, or distrustful? (我是否妒忌、不潔、挑剔、易怒、敏感或懷疑？)
17.How do I spend my spare time? (我如何打發空閒的時間？)
18.Am I proud? (我驕傲嗎？)
19.Do I thank God that I am not as other people, especially as the Pharisees who despised the publican? (我會為自己不像其他人而感謝上帝，特別是不像法利賽人般瞧不起稅吏？)
20.Is there anyone whom I fear, dislike, disown, criticize, hold a resentment toward or disregard? If so, what am I doing about it? (我有否害怕、不喜歡、不認同、批評、憎恨或藐視的人？若有，我要怎樣做？)
21.Do I grumble or complain constantly? (我經常抱怨或投訴嗎？)
22.Is Christ real to me? (基督對我而言，是否真實？)